I found the following information really helpful in setting up the client.
http://www.youtube.com/watch?v=w8AOMJ7voPk&hd=1Quick-setup Guide
Think you're too good to go through the whole tutorial? Or maybe you're just lazy? Try this quick guide. Alternatively, you can use this video tutorial.
Download and install Simba from here.
Open Simba; go to View > Extensions.
Enable extensions.sex.
Click View > Extensions Menu.
Click Extensions > Check for Updates. Let it update.
Restart Simba.
Go to View > Extensions.
Enable srl.sex, and associate.sex.
Click SRL > Check for Updates. Let the files download.
Click MSI > Check for Updates. Let the files download.
Click SPS > Check for Updates. Let the files download; may take a few seconds.
Go to MSI > Run.
Refer to this thread if you need help setting up MSI.
Make sure your graphics settings as bright as possible, everything else as low as possible.
Done!
If it doesn't work, go through the whole guide before posting.
If you set up is anything like mine, you will have trouble with the MSVCR71.dll file. Find a legitimate DL site, unzip the file, copy it, then paste it into your C://windowssysts32 folder.
Happy botting